Make one based on a race war. On the re-election of Barack Hussein Obama to the office of President of the United States, Obama declares open war against the white race. By that point, African-Americans and Latinos will outnumber Caucasians in the United States (at least if you're counting los inmigrantes ilegales with the other Latinos), so it will be a hard battle: black and Latino agents of genocide, filled with hatred against whitey from years of race-baiting and class warfare theories pushed into their head by the very same people who put Obama in the White House, versus a white race conditioned for decades to be filled with white guilt. Make sure to show the crimes committed by these non-whites: murders, lootings, terrorism, torture, slaughter of women and children and senior citizens, rape, whatever. But then, little pockets of resistance appear: usually led by the Ku Klux Klan or by neo-Nazi skinheads, white people begin to fight back. The men in white hoods, once vilified even by their own people for espousing the view that the blacks and Latinos were dangerous and evil, now become heroes, protecting their people from those same dangerous, evil black and Latino hordes. The scene revealing the KKK fighting back might even call back to an earlier scene: three black men, about to kill a white girl, are just about to get started... But in the later scene, a white knight of the KKK comes up and slaughters the three black murderers before they can kill. In the end, the last of the blacks are killed or escape to their true racial homeland on the dark continent, the last of the Hispanics flee to Latin America, and the remnants of the white man are shown with the task of rebuilding the United States.
I'm not a white supremacist. But there's a certain subversive, offensive artistic merit in the idea of such a shocking concept, assuming it were to be executed well. By skewering cultural preconceptions about racial harmony, you could provide a stark contrast to the histories that American children are fed about atrocities committed by the white race. It would shock and offend people into re-examining the white guilt that they've been fed since the African-American civil rights movement started gaining ground, and in doing so may kick down the doors for a more open racial discourse, where I can say that, for example, President Obama and his wife are treating the Presidency like the world's largest and most elaborate welfare check, and people will understand what I mean or at least give me a chance to explain (that Barack and Michelle Obama are spending taxpayer money on personal vacations and other such frivolities without showing any sort of responsibility to the taxpayers who provided it, since they did not have to work to earn that money and so they don't feel any need to be responsible with it) rather than immediately jumping down my throat and comparing me to Adolf Hitler.
OK, a claymation on Newgrounds probably wouldn't do that part. A live-action movie might, but we just don't have that kind of massive cultural influence here. But at least it'll be funny.