Thanks for the feedback, Here's a typical planned layout of a capital character i'm currently working on.
The Captial character it is done in three steps,
Stage (1) I hand draw them the concept
Stage (2) Plan a fixed scale ratio model
Stage (3) Final rendering.
The phrase "Capital Character" is a reference i use when flagging the character who have more sprite frames than most uncommon characters.
Depending on the dilemma i animate it hand drawn then assess the frames for final usage.
The bottom line is that, i find much comfortable to animate sprites hand drawn.
Animating it straight from the PC isn't impossible, but you're limited to options especial y when it's not planned, it really dose depend on the characters condition, certain things like Lip Sychning can be acceptable without the use of it being hand drawn.
When i began this project from scratch, i encountered issues with scale fixing,meaning that nothing was measured or was accurate which is just plain reckless, so yes maths is a big bonus when your animating on a time frame, especially any more than 10 seconds.