Sonic The Hedgehog- Selfless, symbol of freedom.
Roxas (KHII)- Sacrificed his own life to unite with Sora to accomplish something bigger then himself.
Commander Shepard (majority paragon): Taking shit from everybody to preserve his values and crew morale and proving that sometimes justice works better unbound by rules,
Ezio Auditorie (Assasins Creed 2): Had most of his family killed and turned his quest for revenge into a quest of justice.
Leon S. Kinnedy (RE4): Former Raccoon city officer that skilled enough to take down some f the hellish monstrosities ever conceived in a Video Game. His personality is just as awesome.
Professor Gerald: (Sonic Adventure 2) A scientist originally tried to help mankind pulled a 180 after granddaughter was killed by G.U.N His quest for revenge carried on even in death and nearly succeeded with his creations of Shaodw The Hedgehog and Bio-Lizard.
Xemnas (Kingdom Hearts II) leader of organization XIII and their misguided attempt to be whole (human) again.
Sovereign (Mass Effect): This God like organism are in charge of total galactic annihilation in the ME universe. He was able to manipulate and use Saren as distraction from his real plans to destoy all life. Evil, maipulative, elusive the make up of a great villian.
Starkweather (MANHUNT): A sick man that entices (and or abucts) criminals, psychopaths and civilians where they are forced (wheter they like it or not) to partake and in a snuff film where it's kill or be killed.
Gravemind (Halo) :Very much like The Reapers of Mass Effect in the long run. The Gravemind is a parastic creature that wants to infect the entire universe with alien- zombie like creatures. thus destroying all other lifeforms.