There's something very sad about thinking about the last game you'll ever play in your life. Just like one's last meal, or last song they'll hear in their life, or the last movie they'll ever see, that FINAL video game you'll play, that FINAL round, match, or level that you play will be the last you'll enjoy in your existence.
If that is the case, what would you want it to be? Can you imagine that? Being an elderly man, playing one more play-through of Skyrim, finishing just ONE more quest, and then dying of a heart attack the next day? Or playing a round of Counter Strike, not knowing that this is the last game in a long history of playing games.
Personally, I would probably want to play Flower on the PS3. It's pretty tranquil, and it would be a fitting conclusion to a life well spent enjoying games.