Bayonetta had one for me, although it may have just been because I'd stopped playing for a while, came back, and suddenly I could't hit anything. It was the burning / sinking / exploading city level, where it introduces the dog wolf twins, electric and fire.
I loved that game, must play it through again one day.
But other then that, pokemon is the only one I can think of. There's an area in every game where there's no more trainers to grind on, and the wild pokes are to weak to hold up a fight, so you're basicly screwed if you're too weak.