Clickteam will be making a post here soon and helping people get started, but I'll start by echoing what I just posted in the General Forum:
Clickteam, the company that makes The Games Factory 2 and Multimedia Fusion 2, has developed a free Newgrounds editions of The Games Factory 2. This version lets you make games and publish them as SWF to run on NG. You don't need any prior programming experience.
Sexysexybicycle is using Multimedia Fusion 2 to develop his game, Dooder! We're hoping this software will let more people live out their game development dreams. :)
Learn more here!