I suppose I make my traditional attempt to guess/list what I think will be the line up for E3. I'm only going to attempt at Sony/Microsoft because unfortunately I haven't been following Nintendo or most other companies for that matter.
Sony:
-LittleBigPlanet 2 (This year)
-Killzone 3 (This year/Spring 2011)
-InFAMOUS 2 (This year)
-Resistance 3 (2011)
-Gran Turismo 5 (This year)
-Socom 4 (This year)
-The Last Guardian (Spring 2011)
-White Knight Chronicles 2 bundled with the original.
-Move priced and release date. Will be around $70 with camera and the remote. Will have a disc with a bunch of demos on it.
-Teaser for next God of War installment
-Jaffe's game IS NOT Twisted Metal but it is teased despite him saying it isn't.
-Mandatory PSN exclusives
-Final year of the PS2
-A rebranded PSP is shown.
Microsoft:
-Halo: Reach
-Gears of War 3
-Crackdown 2
-Fable III
-Portal 2
-Half Life 2: Episode 3 is PC/360 exclusive.
-Joy Ride is now a full fledge retail game. Redesigned to launch with Natal
-Natal's true name/price/release date announced. Around same price as Move
-A whole slew of Natal games announced and shown. A mix of old IPs and some new "party" games.
-Natal will be bundled with the 360
-Mandatory XBLA exclusive games
-Hulu partnership
-Some new exclusive games shown for the 360.