back in my days of drug use; i was quite knowledgeable about psychoactives and deliriants.
salvia is a strange drug; the user either gets very light-headed and goofy, or has a short trip with an insane experience. extracts usually work the best, but by no means is it a weak drug.
datura is a piece of shit drug; my friends picked a whole bunch of those "seedpods" and sold them to kids. no one has a good experience on datura; it's a deliriant, and causes the mind to go into a fever-induced hell more or less. an acquaintance ended up going to the hospital, and my experiences were FAR from comfortable, and I didn't even take enough seeds to get delirious.
not worth it
the Ayahuasca brew is a favorite amongst spiritualists; it's hard to come by since it's derived from a specific root. i've only known one person who has ventured down that dream. he said he traveled into his mind, and landed on an armchair only to talk to fragments of his ego or some shit. i heard it's not particularly enjoyable, but the experience is usually very revealing and soul-satisfying.
morning glory is also popular, but nurseries began adding chemical agents to it to prevent people from using it recreationally, though I heard there are ways around it.
shrooms are fun; don't pick wild mushrooms :)
DMT is probably the most powerful drug known to man, but like other intense drugs; there's no real high, just a full out trip.
the only plants that make you feel good are weed, the poppy plant, the coca plant, nutmeg? and i suppose mushrooms IF you want to classify them as such.
i'm sure there are others, but i haven't done any research in a VERY long time.
TL;DR weed, opium, heroin, cocaine blah blah blah drugs are bad