1. L4D2
The original one was very good based on it's replayability and I made some friends on there, and based on the facts it'll live up to it's original and beyond.
2. Dead Rising 2
Screw you guys for not mentioning this. This time round you're Chuck Greene (sp?), some motorist who is in the infected town of Fortune City. Bit blurry on the details but from what I heard it will be a good time (and with multiplayer I believe).
3. COD:MW2
(Yes, its a CoD game guys and girls) Lot of good features are being put into this (including customized kill streaks) along with a good storyline.
4. Dead Space 2
The original Dead Space was very good even if some think it's RE4 in space, so I'm hoping for the same amount of quality from it's precedent (Upside down shooting is always fun!). And Isaac
5. Starcraft 2
With a truck load of missions, I doubt it will disappoint, and Blizzard usually doesn't. Plus with the trailers I viewed it will be much more tactical and if the map creator is in there also, that days of playing there.
6. Halo: ODST
Even with my lack of info on the game, reading the books makes me hunger for this. Considering there's a lot of crap that the Halo games didn't cover, I'd love to see some of that in this. Plus the lack of the high tech armor probably means more tactics are involved.
7. Mass Effect 2
With the ending of Mass Effect, this brings up a hell of a lot of shit to go down and I believe it is going to be more open ended than the original. Basically it's going to be fun.
Fallout: New Vegas
It's using the Oblivion engine I believe so it will still have that feel that I like but with some new people developing it, more than likely be some cool stuff.
That's that folks. It really isn't in order but still.