In banjo-tooie on Hail-frost peak there are these little BASTARD flame dudes on magic carpets that LAUGH as they try to attack you and when you miss them... IT REALLY GET'S YOUR BLOOD BOILING. however this make all the better when you actually kill them! =D
Also Doctor Carol from Perfect Dark.... "Do actually know what you doing?" NOOOOOOOO!!! ALRIGHT!!! NOW WILL YOU SHUT UP!!!!!!!1111!!11
...too bad you can't kill him.... and complete the mission. >:)