MA5B / MA5C from Halo: CE and Halo 3 - the workhorse firearm for the UNSC troops, offering good capacity of ammunition, unrelenting firepower, substantial damage, and the ability to tear up hordes of covenant and flood foes. It's pretty beast in multiplayer (MA5C) and served the UNSC forces well, especially Master Chief.
AK-47 - In many games, this is the classic and iconic assault rifle. In Call of Duty 4, this is an absolute killing machine. GTA 4, offers immense firepower and morale, in Project Reality it serves my insurgent cause well, and in numerous other games the AK-47 is a dazzling weapon of choice, just like its real life counter part.
M1911 Colt .45 - In every game I play, this pistol offers the classic great handgun accuracy, powerful clips, and reliability. In CoD4, I whip this out with a silencer attached and finish off an opponent when my M4 Carbine's clip runs out.
Super Shotgun from Doom II - *BOOM!* *CLOP!* *BOOM!* This gun defines Doom for me, pumping a hellish torrent of lead at demons and enemies online. One shot, one kill (or a lot of damage)
Kar 98k
MP40
Halo 3 Battle Rifle
Halo: Combat Evolved Pistol
M4A1 Carbine
BFG 9000 from Doom
Mosin Nagant
MP5
Crysis Sniper
M21
Halo shotgun
Gravity Gun
Crossbow from Half Life 2