Oh yey, I killed Wadolf. Now for the medals!
Also, more than one useful guide has been posted here, but I think I will give you my version, just for the fun of it. I will concentrate mostly on bosses and generally disturbing things.
Ahem.
First boss: BigFuzzyKitten.
He is big, and damn is he fuzzy! My method of handing his ass to him involves a certain risk, but if you get it right, it can be very rewarding. Run to either of the top corners, so that he also will move upwards. Avoid his minions, and then quickly run beneath him. When he summons his yarnbomb, continue running down and away from it, and he will run his own superweapon and decimate his own HP severely. Repeat until the fucker says his final meow, kill his cronies if they are not dead yet, and move on
Second boss: PsychoGoldfish.
Watch out for his flying-fish attack at all costs, if you are unlucky, it will continue to hit you until you are either dead or as good as. Moving up and down a lot will minimize risks. This fuckers weakness is his own ego, he will often pause to laugh at you, and then you can safely give him a good three-hit answer. If you manage to avoid his barrage of fish, he will huff and puff like a bicycle-pump, and again can you give him a resounding whopping. Whatever you do though, never engage in a fight with him if he is up and running, he can counter like a son-of-a-bitch on occassion, and chances are his underlings will utterly mangle you to top it off.
Third boss: Mindchamber.
He might look tough, but he is slower than a grandma and provides you with a perfect tool to destroy him: his own homing bombs. Making these hit him or his servants is the key to mangling him, just stay out of his VERY long reach by moving towards the edges and up and down a lot until he launches his bombs at you. When you manage to get these to hit him, he will fall sooner than you might think.
Fourth boss: Stamper and Jeff.
Your main concern in this battle is Stamper. The man counters like a motherfucker, and if you play as Tom, he is almost on par with your speed. But he is nearly harmless when he is up in the air, that is your chance. Mangle away at him, and when he falls down, just run away until Jeff sends him up in the air again. Engaging him in a fair fight is a no-no. As for Jeff, he is much slower than Stamper and can be successfully juggled once Stamper is out of the picture.
Fifth and final boss: Wadolf.
Avoid his Laz0r. That is all you need to be concerned about. His minions can be tricked to running into this ray of death however, and this is an effective way to get rid of them. You can safely toss a bomb at him from behind him while he is firing his Laz0r, and I recommend this approach greatly. Those are the two things you need to do in order to beat him, you can engage the zombies if you want to, but I strongly suggest you just avoid them until Wadolf is history.
Anything else?
Save the guts until you have defeated Mindchamber, then you get the opportunity to receive full health. Any and all guts should be consumed after this point.
Although it depends on which character you play as, you might want to take an avoiding role on most boss battles, and also on the later regular battles. Exploit the weakness of your foe to the max, and this game is yours.