is this even a serious question?
we could almost lose to every single animal in the animal kingdom without using weapons.
but our opposable thumbs and brains make us far superior.
im pretty sure some breeds of dogs could take us down. they get a good hold on your arm and bring you down, then they go for the neck. your done.
any horse would probably trample us to death. I mean how do u even hurt a horse with fists? u cant break its neck.
a bear? please. thats a fucking joke. we have zero chance with only fists.
and a fucking ape? the only people that could even put up some kind of fight against an ape is like 'the big show' and huge body builders. maybe UFC champs. that animal is beastly. if i was put in a cage fight with an ape i would shit myself.