Alright, I've been playing guitar for 8 years, and in all of those 8 years I've tried every guitar I can get my hands on. PRS, Carvin, Fernandes, ESP (LTD), Gibson, Fender etc.
Personally, I've only owned two guitars, a Kona (Strat-Knock-off) and I currently own a completely custom Epiphone Les Paul, that I use to play anything from rock, classic rock, hip-hop, jazz, blues, heavy metal, etc.
My Les Paul is fitted with a Fernandes humbucking sustainer, a Lace Sensor Emerald in the middle and a DiMarzio EVO2 in the bridge. The EVO2 can be coil tapped for a single pickup sound.
There are still the four stock knobs for volume and tone but they are only wired to the Lace and the DiMarzio and the Fernandes can be turned on and off with a simple two-way switch. I have a Les-Trem which is a tremolo system that doesn't require any drilling or anything it just sits on the standard bridge.
Uh.. What else.. I swear there's something I'm missing.. That might be it.. Yeah, that's all.
The guitar is like, $449 new from Guitar Center and then with all the shit I have on mine it'll cost you around $1,000.
OH!
If you do this, make sure you replace all the potentiometers and wiring, have it done by a professional unless you're experienced with wiring... Also, replace the strings. For you I'd recommend 10-46's, that's what I use.
Hopefully I helped a bit.
I would also recommend looking at PRS, Fender Fat-Strats, Carvin (DC series or CT series), stuff like that.
Best of luck. (: