Newgrounds.com — Everything, By Everyone.

So I've always been interested in doing animation, much likethis person.
I've already dabbled a bit with Photoshop CS6, discovered timeline but I'm still very new to the program in general in regards for animation. So I have many questions.

What presets do you recommend for exporting to youtube? (ex. should I use the default Film and Media template or should I make my own edits to the settings?)

How many frames should I copy to get a smooth animation? Is it possible to change the framerate in Photoshop at all?

And finally, for coloring animation is using group folders a good idea? I had the idea of trying that yesterday but I was on a bad laptop so even attempting to make a group folder made the laptop super hot quickly.

Thank you very much for any responses!