Ahhh, nova. How much I enjoyed playing this frame. Obliterating everything in a radius of about 5 square kilometers with molecular prime and an arrow. Good times :)

The lineart and coloring is very clean. You also did a good job at actualy making her look like nova. Most of the defining details have been taken into account and implemented. I also can't find mayor flaws anatomy-wise.
But it isn't all without flaw. The light emitting from her right fist looks dim and unrefined. A bit more time working it out would have brought better results. That you used it to create an ambient lighting around novas head and shoulder is very good. On that subject, slightly stronger highlights could have improved the effect of said ambience. Same goes for the antimatter containers on her back and head ( I had a hard time figuring out what these things are in game. I just consider them as some sort of containers ).

Overall, a good work. It's a clean, charming fanart that stays true to its source material.